Article

Alterations to parvalbumin-expressing interneuron function and associated network oscillations in the hippocampal – medial prefrontal cortex circuit during natural sleep in App <sup>NL-G-F</sup> mice

2022-02-10

Abstract excerpt

In the early stages of Alzheimer’s disease (AD), the accumulation of the peptide amyloid-β (Aβ) damages synapses and disrupts neuronal activity and leads to disruption of neuronal oscillations associated with cognition. This is thought to be largely due to impairments in CNS synaptic inhibition, particularly via parvalbumin (PV)-expressing interneurons that essential for generating several key oscillations. Resear...

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Literature Corpus work: 5182c5d7-a899-588d-9c62-2ba43452a0f1
DOI: 10.1101/2022.02.08.479119

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