Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Amyloid β induces interneuron-specific changes in the hippocampus of APPNL-F mice.

PloS one - 1 Jan 2020

Sos Katalin E, Mayer Márton I, Takács Virág T, Major Abel, Bardóczi Zsuzsanna, Beres Barnabas M, Szeles Tamás, Saito Takashi, Saido Takaomi C, Mody István, Freund Tamás F, Nyiri Gábor

Abstract excerpt

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline and amyloid-beta (Aβ) depositions generated by the proteolysis of amyloid precursor protein (APP) in the brain. In APPNL-F mice, APP gene was humanized and contains two familial AD mutations, and APP-unlike other mouse models of AD-is driven by the endogenous mouse APP promoter. Similar to people without apparent cognitive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Peptides
Share to Axons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hippocampus

Share to Interneurons

Share to Memory, Short-Term

Share to Nerve Net

Share to Pyramidal Cells

Share to Receptors, GABA-A

Source

Open in PubMed Open full text

Identifiers

PMID: 32469963
DOI: 10.1371/journal.pone.0233700
PMCID: PMC7259556

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Amyloid β induces interneuron-specific changes in the hippocampus of APPNL-F mice.PMID 32469963Read ↗

Differential expression of interneuron populations and correlation with amyloid-β deposition in the olfactory cortex of an AβPP/PS1 transgenic mouse model of Alzheimer's disease.Semantic proximity Read ↗

Hippocampal interneuron loss in an APP/PS1 double mutant mouse and in Alzheimer’s diseaseSemantic proximity Read ↗

Regional interneuron transcriptional changes reveal pathologic markers of disease progression in a mouse model of Alzheimer’s diseaseSemantic proximity Read ↗

APPsα Rescues Tau-Induced Synaptic PathologySemantic proximity Read ↗

An Intracellular Amyloid-β/AβPP Epitope Correlates with Neurodegeneration in those Neuronal Populations Early Involved in Alzheimer's Disease.Semantic proximity Read ↗

Alterations to parvalbumin-expressing interneuron function and associated network oscillations in the hippocampal – medial prefrontal cortex circuit during natural sleep in App <sup>NL-G-F</sup> miceSemantic proximity Read ↗

Age-related changes of neuron numbers in the frontal cortex of a transgenic mouse model of Alzheimer's disease.Semantic proximity Read ↗

Comparison of memory, affective behavior, and neuropathology in APPNLGF knock-in mice to 5xFAD and APP/PS1 miceSemantic proximity Read ↗

Early neuropathology of somatostatin/NPY GABAergic cells in the hippocampus of a PS1×APP transgenic model of Alzheimer's diseaseSemantic proximity Read ↗

Characterization of adult hippocampal neurogenesis in the novel <i> App <sup>SAA</sup> </i> Knock-in Alzheimer’s disease mouse modelSemantic proximity Read ↗

Early neuronal loss and axonal/presynaptic damage is associated with accelerated amyloid-β accumulation in AβPP/PS1 Alzheimer's disease mice subiculum.Semantic proximity Read ↗

Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer's disease: analysis of Osaka mutation-knockin mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.