Article

Long Wake/Short Sleep Bouts and Hyperactivity with Advanced Age in a Mouse Model of Early Onset Alzheimer’s Disease

2025-12-29

Abstract excerpt

Poor sleep quality and reduced sleep duration are associated with Alzheimer’s disease (AD)-related β-amyloid (Aβ) pathologies. We conducted two studies of sleep/wake, activity and body temperature in App NL-G-F mice, a strain that exhibits three mutations in the human App gene associated with elevated risk for early onset AD. First, App NL-G-F mice were compared to wildtype (WT) littermates at 14-18 and 18-22 m...

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Literature Corpus work: 95700405-0ccb-5790-a1ed-aa5fd628631e
DOI: 10.64898/2025.12.29.696818

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