Article
Neural oscillations during cognitive processes in an App knock-in mouse model of Alzheimer's disease pathology.
Scientific reports - 8 Nov 2019
Jacob Sofia, Davies Gethin, De Bock Marijke, Hermans Bart, Wintmolders Cindy, Bottelbergs Astrid, Borgers Marianne, Theunis Clara, Van Broeck Bianca, Manyakov Nikolay V, Balschun Detlef, Drinkenburg Wilhelmus H I M
Abstract excerpt
Multiple animal models have been created to gain insight into Alzheimer's disease (AD) pathology. Among the most commonly used models are transgenic mice overexpressing human amyloid precursor protein (APP) with mutations linked to familial AD, resulting in the formation of amyloid β plaques, one...
Topics
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Animals
- Behavior, Animal
- Brain Waves
- Cognition
- Discrimination Learning
- Disease Models, Animal
- Gene Knock-In Techniques
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic