Article

Early Loss of Deep Restorative Sleep and Auditory Stimulus Evoked 40-Hz activity of Hippocampal Parvalbumin Neurons in the APP/PS1 Mouse Model of Alzheimer’s Disease

2026-05-29

Abstract excerpt

<h4>ABSTRACT</h4> Sleep abnormalities and dysfunction of gamma band (30–80 Hz) activity generated by parvalbumin (PV) interneurons are early characteristics of Alzheimer’s disease (AD) which correlate with the severity of amyloid-β deposition (Aβ) and cognitive impairment. However, the timing of these alterations in vivo with respect to disease progression is unclear. Here, in longitudinal recordings from APP/PS...

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Literature Corpus work: 1a9dcbe5-f367-5ec1-8d02-7fc89a509713
DOI: 10.64898/2026.05.26.725476

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