Article

Non-cell-autonomous regulation of germline proteostasis by insulin/IGF-1 signaling via the intestinal peptide transporter PEPT-1

2024-02-25

Abstract excerpt

Gametogenesis involves active protein synthesis and heavily relies on proteostasis. How animals regulate germline proteostasis at the organismal level is poorly understood. Taking C. elegans as a model, we show that germline proteostasis requires coupled activities of HSF-1-dependent protein folding and insulin/IGF-1 signaling controlled protein synthesis. Depletion of HSF-1 from germ cells impairs chaperone gene...

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Identifiers and source

Literature Corpus work: 5181a92b-d8f0-50cd-af78-d9ddd5e8c72a
DOI: 10.1101/2024.02.22.581543

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Non-cell-autonomous regulation of germline proteostasis by insulin/IGF-1 signaling via the intestinal peptide transporter PEPT-1DOI 10.1101/2024.02.22.581543Read

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