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Starvation-induced changes in somatic insulin/IGF-1R signaling drive metabolic programming across generations

7 Apr 2023

Abstract excerpt

Exposure to adverse nutritional and metabolic environments during critical periods of development can exert long-lasting effects on health outcomes of an individual and its descendants. Although such metabolic programming has been observed in multiple species and in response to distinct nutritional stressors, conclusive insights into signaling pathways and mechanisms responsible for initiating, mediating, and...

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PMID: 37027477
DOI: 10.1126/sciadv.ade1817

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