Germline stem cell arrest inhibits the collapse of somatic proteostasis early in <i>Caenorhabditis elegans</i> adulthood

Abstract excerpt

All cells rely on highly conserved protein folding and clearance pathways to detect and resolve protein damage and to maintain protein homeostasis (proteostasis). Because age is associated with an imbalance in proteostasis, there is a need to understand how protein folding is regulated in a multicellular organism that undergoes aging. We have observed that the ability of Caenorhabditis elegans to maintain...

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