Article

Eukaryotic Initiation Factor 5A2 localizes in actively translating ribosomes to promote cell protrusions and invasion of cancer cells

2022-12-19

Abstract excerpt

<title>Abstract</title><p>Background Eukaryotic Initiation Factor 5A (eIF-5A), an essential translation factor, is post-translationally activated by the polyamine spermidine. Two human genes encode eIF-5A, being eIF5-A1 constitutively expressed whereas eIF5-A2 is frequently found overexpressed in human tumours. The contribution of both isoforms with regard to cellular proliferation and invasion in non-small cell l...

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Literature Corpus work: 515bb5c2-7c05-5180-a513-cc2ef1e6614e
DOI: 10.21203/rs.3.rs-2379535/v1

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