Article

Archaic translation initiation factor eIF5B supports KSHV late lytic replication and viral oncogenesis by mimicking a hypoxic cellular landscape

2026-02-26

Abstract excerpt

<h4>ABSTRACT</h4> Kaposi’s Sarcoma (KS) Herpesvirus (KSHV) is the etiological agent of KS, an AIDS-defining illness. Recent studies have demonstrated that even during normoxic conditions, KSHV facilitates replication by modulating hypoxia-inducible factors (HIFs), creating a hypoxia-like environment that promotes cellular transformation. KSHV lytic viral genes are favored for protein synthesis during infection by...

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Literature Corpus work: f88ceb05-cf2d-5902-a144-4fd4c06106d0
DOI: 10.64898/2026.02.23.707408

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