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The eEF1A Proteins: At the Crossroads of Oncogenesis, Apoptosis, and Viral Infections

7 Apr 2015

Abstract excerpt

Eukaryotic translation elongation factors 1 alpha, eEF1A1 and eEF1A2, are not only translation factors but also pleiotropic proteins that are highly expressed in human tumors, including breast cancer, ovarian cancer, and lung cancer. eEF1A1 modulates cytoskeleton, exhibits chaperone-like activity and also controls cell proliferation and cell death. In contrast, eEF1A2 protein favors oncogenesis as shown by the...

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PMID: 25905039
DOI: 10.3389/fonc.2015.00075

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