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Eukaryotic elongation factor 2 kinase upregulates the expression of proteins implicated in cell migration and cancer cell metastasis

13 Dec 2017

Abstract excerpt

Eukaryotic elongation factor 2 kinase (eEF2K) negatively regulates the elongation phase of mRNA translation and hence protein synthesis. Increasing evidence indicates that eEF2K plays an important role in the survival and migration of cancer cells and in tumor progression. As demonstrated by two‐dimensional wound‐healing and three‐dimensional transwell invasion assays, knocking down or inhibiting eEF2K in cancer...

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PMID: 29235102
DOI: 10.1002/ijc.31210

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