Article

Beta HPV8 E6 Induces Micronuclei Formation and Promotes Chromothripsis

2022-02-08

Abstract excerpt

Cutaneous beta genus human papillomaviruses (β-HPV) are suspected to promote the development of non-melanoma skin cancer (NMSC) by destabilizing the host genome. Multiple studies have established the genome destabilizing capacities of β-HPV proteins E6 and E7 as a co-factor with UV. However, the E6 protein from β-HPV8 (HPV8 E6) induces tumors in mice without UV exposure. Here, we examined a UV-independent mechanis...

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Literature Corpus work: 514c7563-9241-584e-93af-dc3674912af7
DOI: 10.1101/2022.02.03.479074

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