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Beta Human Papillomavirus 8 E6 Induces Micronucleus Formation and Promotes Chromothripsis

21 Sept 2022

Abstract excerpt

Some beta genus human papillomaviruses (β-HPVs) may promote skin carcinogenesis by inducing mutations in the host genome. Supporting this, the E6 protein from β-HPV8 (8 E6) promotes skin cancer in mice with or without UV exposure. Many mechanisms by which 8 E6 increases mutations caused by UV have been elucidated, but less is known about how 8 E6 induces mutations without UV. We address that knowledge gap by...

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PMID: 36129261
DOI: 10.1128/jvi.01015-22

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