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High-risk human papillomavirus oncogenes disrupt the Fanconi anemia DNA repair pathway by impairing localization and de-ubiquitination of FancD2

28 Feb 2019

Abstract excerpt

Persistent expression of high-risk HPV oncogenes is necessary for the development of anogenital and oropharyngeal cancers.Here, we show that E6/E7 expressing cells are hypersensitive to DNA crosslinking agent cisplatin and have defects in repairing DNA interstrand crosslinks (ICL).Importantly, we elucidate how E6/E7 attenuate the Fanconi anemia (FA) DNA crosslink repair pathway.Though E6/E7 activated the pathway...

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PMID: 30818369
DOI: 10.1371/journal.ppat.1007442

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