Article

Beta human papillomavirus 8E6 promotes alternative end-joining

2022-07-30

Abstract excerpt

Double strand breaks (DSBs) are one of the most lethal DNA lesions in cells. Previous studies show that the E6 protein of beta-human papillomavirus (HPV8 E6) impairs two major DSB repair pathways homologous recombination (HR) and non-homologous end-joining (NHEJ). However, HPV8 E6 delays but does not eliminate DSB repair capability of cells. How DSBs are repaired in cells with HPV8 E6 remains to be studied. We hyp...

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Literature Corpus work: 00cb674b-ad1b-5725-a6af-6939bbacfd33
DOI: 10.1101/2022.07.29.501983

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