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The Causes and Consequences of DNA Damage and Chromosomal Instability Induced by Human Papillomavirus

25 Apr 2024

Abstract excerpt

High-risk human papillomaviruses (HPVs) are the main cause of cervical, oropharyngeal, and anogenital cancers, which are all treated with definitive chemoradiation therapy when locally advanced. HPV proteins are known to exploit the host DNA damage response to enable viral replication and the epithelial differentiation protocol. This has far-reaching consequences for the host genome, as the DNA damage response is...

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PMID: 38730612
DOI: 10.3390/cancers16091662

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