Article

Cutaneous human papillomavirus E6 impairs the cGAS-STING pathway

2024-12-05

Abstract excerpt

Beta genus human papillomaviruses (β-HPVs) are ubiquitous double stranded DNA (dsDNA) viruses that may promote skin cancers by destabilizing the host genome. Supporting this, expression of the E6 gene from a β-HPV (β-HPV 8 E6) results in increased micronuclei that should induce an innate immune response that eliminates these cells. Yet, β-HPV 8 E6 promotes rather than restricts proliferation. We hypothesize that β...

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Literature Corpus work: 7868667e-58f9-5b02-8e20-f3f3b22eff3e
DOI: 10.1101/2024.11.29.625575

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