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Article

Proteasome assembly triggers a switch required for active-site maturation.

Structure (London, England : 1993) - 1 Jul 2006

Witt Susanne, Kwon Young Do, Sharon Michal, Felderer Karin, Beuttler Mirjam, Robinson Carol V, Baumeister Wolfgang, Jap Bing K

Abstract excerpt

The processing of propeptides and the maturation of 20S proteasomes require the association of beta rings from two half proteasomes. We propose an assembly-dependent activation model in which interactions between helix (H3 and H4) residues of the opposing half proteasomes are prerequisite for appropriate positioning of the S2-S3 loop; such positioning enables correct coordination of the active-site residue needed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16843899
DOI: 10.1016/j.str.2006.05.019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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