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Nicotinamide Riboside and Metformin Ameliorate Mitophagy Defect in Induced Pluripotent Stem Cell-Derived Astrocytes With POLG Mutations

24 Sept 2021

Abstract excerpt

Mitophagy specifically recognizes and removes damaged or superfluous mitochondria to maintain mitochondrial homeostasis and proper neuronal function. Defective mitophagy and the resulting accumulation of damaged mitochondria occur in several neurodegenerative diseases. Previously, we showed mitochondrial dysfunction in astrocytes withPOLGmutations, and here, we examined howPOLGmutations affect mitophagy in...

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PMID: 34631714
DOI: 10.3389/fcell.2021.737304

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