Article

Impaired neutrophil-mediated cell death drives Ewing’s Sarcoma in a two years old child with Down Syndrome

2023-05-31

Abstract excerpt

<h4>Summary</h4> Ewing’s Sarcoma (EWS) has been reported in seven children with Down Syndrome (DS). To date, a detailed assessment of this solid tumor in DS patients is still missing. Here, we characterized a chemo-resistant mediastinal EWS in a 2-year-old DS child, the youngest ever reported case, by exploiting sequencing approaches. The tumor showed a neuroectodermal development driven by the EWSR1-FLI1 fusion....

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Literature Corpus work: 511f3dbf-ca78-5c20-a277-14bf2f1c1846
DOI: 10.1101/2023.05.30.23289664

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