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Sensitive GATA1 mutation screening reliably identifies neonates with Down syndrome at risk for myeloid leukemia

22 Jan 2021

Abstract excerpt

Children with Down syndrome (DS) have a higher chance of developing myeloid neoplasms as compared to healthy children [ 1 ]. Therefore, the World Health Organization (WHO) classifies myeloid neoplasms associated with DS as separate from other myeloid neoplasms. The most recent WHO classification defines transient abnormal myelopoiesis (TAM) in children with DS as “increased peripheral blood (PB) blast cells in a...

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PMID: 33483616
DOI: 10.1038/s41375-021-01128-1

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