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Article

Tumorigenesis in Down's syndrome: big lessons from a small chromosome.

Nature reviews. Cancer - 1 Oct 2012

Nižetić Dean, Groet Jürgen

Abstract excerpt

If assessed by a number of criteria for cancer predisposition, Down's syndrome (DS) should be an overwhelmingly cancer-prone condition. Although childhood leukaemias occur more frequently in DS, paradoxically, individuals with DS have a markedly lower incidence of most solid tumours. Understanding the mechanisms that are capable of overcoming such odds could potentially open new routes for cancer prevention and...

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Identifiers

PMID: 22996602
DOI: 10.1038/nrc3355

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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