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Article

Tumorigenesis in Down's syndrome: big lessons from a small chromosome.

Nature reviews. Cancer - 1 Oct 2012

Nižetić Dean, Groet Jürgen

Abstract excerpt

If assessed by a number of criteria for cancer predisposition, Down's syndrome (DS) should be an overwhelmingly cancer-prone condition. Although childhood leukaemias occur more frequently in DS, paradoxically, individuals with DS have a markedly lower incidence of most solid tumours. Understandin...

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Identifiers

PMID: 22996602
DOI: 10.1038/nrc3355

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22996602-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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