Article
Acute myeloid leukemia with an MN1-ETV6 fusion in a young child with Down syndrome.
Cold Spring Harbor molecular case studies - 1 Apr 2022
Rosenzweig Jaclyn, Pillai Pallavi M, Prockop Susan, Benayed Ryma, Eidenschink Brodersen Lisa, Najfeld Vesna, Loken Michael R, Zhang Yanming, Shukla Neerav
Abstract excerpt
Myeloid leukemia of Down syndrome (ML-DS) in young children is associated with distinct clinical and biological features and is typically initiated with oncogenic mutations in the X-linked megakaryocytic transcription factor GATA1. Here we present a 3-yr-old child with DS diagnosed with acute myeloid leukemia (AML), which lacks typical immunophenotypic and molecular characteristics of ML-DS, including GATA1...
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