Article
Genomic landscape of Down syndrome-associated acute lymphoblastic leukemia.
Blood - 13 Jul 2023
Li Zhenhua, Chang Ti-Cheng, Junco Jacob J, Devidas Meenakshi, Li Yizhen, Yang Wenjian, Huang Xin, Hedges Dale J, Cheng Zhongshan, Shago Mary, Carroll Andrew J, Heerema Nyla A, Gastier-Foster Julie, Wood Brent L, Borowitz Michael J, Sanclemente Lauren, Raetz Elizabeth A, Hunger Stephen P, Feingold Eleanor, Rosser Tracie C, Sherman Stephanie L, Loh Mignon L, Mullighan Charles G, Yu Jiyang, Wu Gang, Lupo Philip J, Rabin Karen R, Yang Jun J
Abstract excerpt
Trisomy 21, the genetic cause of Down syndrome (DS), is the most common congenital chromosomal anomaly. It is associated with a 20-fold increased risk of acute lymphoblastic leukemia (ALL) during childhood and results in distinctive leukemia biology. To comprehensively define the genomic landscape of DS-ALL, we performed whole-genome sequencing and whole-transcriptome sequencing (RNA-Seq) on 295 cases. Our...
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