Article

Differential expression of Ormdl genes in the islets of mice and humans with obesity

2019-08-05

Abstract excerpt

<h4>Summary</h4> The orosomucoid-like proteins (Ormdl1-3) are emerging as the critical regulators of sphingolipid homeostasis, inflammation and ER stress. However, their roles in β-cells and obesity remain unknown. Here, we showed that islets isolated from overweight/obese human donors displayed marginally reduced ORMDL1-2 expression while ORMDL3 expression was significantly reduced as compared to islets from l...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 511b0fd6-d532-5c1a-8db9-b0ffc8cd6998
DOI: 10.1101/715599

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Differential expression of Ormdl genes in the islets of mice and humans with obesityDOI 10.1101/715599Read

Differential Expression of Ormdl Genes in the Islets of Mice and Humans with ObesitySemantic proximity Read

Lipid droplets protect human β cells from lipotoxic-induced stress and cell identity changesSemantic proximity Read

Identification of islet-enriched long non-coding RNAs contributing to β-cell failure in type 2 diabetesSemantic proximity Read

Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion.Semantic proximity Read

14-3-3ζ constrains insulin secretion by regulating mitochondrial function in pancreatic β-cellsSemantic proximity Read

STAT3 Regulates Mitochondrial Gene Expression in Pancreatic β-Cells and Its Deficiency Induces Glucose Intolerance in ObesitySemantic proximity Read

RIPK3-mediated inflammation is a conserved β cell response to ER stressSemantic proximity Read

Adaptation and failure of pancreatic beta cells in murine models with different degrees of metabolic syndrome.Semantic proximity Read

Lipotoxicity Induces Beta Cell Small Extracellular Vesicle-mediated β-cell DysfunctionSemantic proximity Read

Leptin Signalling in the Ovary of Diet-Induced Obese Mice Regulates Activation of Nod-Like Receptor Protein 3 InflammasomeSemantic proximity Read

IER3IP1 is critical for maintaining glucose homeostasis through regulating the endoplasmic reticulum function and survival of β cellsSemantic proximity Read

Macrophage-associated pro-inflammatory state in human islets from obese individualsSemantic proximity Read