Article
Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion.
Molecular metabolism - 1 Apr 2017
Cruciani-Guglielmacci Céline, Bellini Lara, Denom Jessica, Oshima Masaya, Fernandez Neïké, Normandie-Levi Priscilla, Berney Xavier P, Kassis Nadim, Rouch Claude, Dairou Julien, Gorman Tracy, Smith David M, Marley Anna, Liechti Robin, Kuznetsov Dmitry, Wigger Leonore, Burdet Frédéric, Lefèvre Anne-Laure, Wehrle Isabelle, Uphues Ingo, Hildebrandt Tobias, Rust Werner, Bernard Catherine, Ktorza Alain, Rutter Guy A, Scharfmann Raphael, Xenarios Ioannis, Le Stunff Hervé, Thorens Bernard, Magnan Christophe, Ibberson Mark
Abstract excerpt
OBJECTIVE: In type 2 diabetes (T2D), pancreatic β cells become progressively dysfunctional, leading to a decline in insulin secretion over time. In this study, we aimed to identify key genes involved in pancreatic beta cell dysfunction by analyzing multiple mouse strains in parallel under metabolic stress. METHODS: Male mice from six commonly used non-diabetic mouse strains were fed a high fat or regular chow...
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