Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

STAT3 Regulates Mitochondrial Gene Expression in Pancreatic β-Cells and Its Deficiency Induces Glucose Intolerance in Obesity

28 Jun 2021

Abstract excerpt

Most obese and insulin-resistant individuals do not develop diabetes. This is the result of the capacity of β-cells to adapt and produce enough insulin to cover the needs of the organism. The underlying mechanism of β-cell adaptation in obesity, however, remains unclear. Previous studies have suggested a role for STAT3 in mediating β-cell development and human glucose homeostasis, but little is known about STAT3...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes and associated disorders
Share to Metabolism, Diabetes, and Cancer
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34183374
DOI: 10.2337/db20-1222

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

STAT3 Regulates Mitochondrial Gene Expression in Pancreatic β-Cells and Its Deficiency Induces Glucose Intolerance in ObesityPMID 34183374Read ↗

Zmiz1 is required for mature β-cell function and mass expansion upon high fat feedingSemantic proximity Read ↗

STAT3 as a mediator of oncogenic cellular metabolism: Pathogenic and therapeutic implicationsSemantic proximity Read ↗

STAT3 sensitizes insulin signaling by negatively regulating glycogen synthase kinase-3 beta.Semantic proximity Read ↗

A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance.Semantic proximity Read ↗

A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell toleranceSemantic proximity Read ↗

STAT1 dissociates adipose tissue inflammation from insulin sensitivity in obesitySemantic proximity Read ↗

Histone Deacetylase 3 Regulates Adipocyte Phenotype at Early Stages of Differentiation.Semantic proximity Read ↗

Differential expression of Ormdl genes in the islets of mice and humans with obesitySemantic proximity Read ↗

Tissue-specific disruption of Kbtbd2 uncovers adipocyte-intrinsic and -extrinsic features of the teeny lipodystrophy syndrome.Semantic proximity Read ↗

Differential Expression of Ormdl Genes in the Islets of Mice and Humans with ObesitySemantic proximity Read ↗

14-3-3ζ constrains insulin secretion by regulating mitochondrial function in pancreatic β-cellsSemantic proximity Read ↗

Diabetes-associated <i>MYT1</i> and <i>ST18</i> regulate human beta-cell insulin secretion and survival via other diabetes-risk genesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.