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Macrophage-associated pro-inflammatory state in human islets from obese individuals

2 Dec 2019

Abstract excerpt

Obesity is associated with inflammatory macrophages in insulin responsive tissues and the resulting inflammatory response is a major contributor to insulin resistance. In insulin-producing pancreatic islets, the intra-islet accumulation of macrophages is observed in patients of type 2 diabetes (T2D), but such has not been investigated in obese individuals. Here, we show that pro-inflammatory cytokines (IL-1β,...

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PMID: 31787760
DOI: 10.1038/s41387-019-0103-z

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