Article
Adaptation and failure of pancreatic beta cells in murine models with different degrees of metabolic syndrome.
Disease models & mechanisms - 1 Jan 2000
Medina-Gomez Gema, Yetukuri Laxman, Velagapudi Vidya, Campbell Mark, Blount Margaret, Jimenez-Linan Mercedes, Ros Manuel, Oresic Matej, Vidal-Puig Antonio
Abstract excerpt
The events that contribute to the expansion of beta-cell mass and enhanced beta-cell function in insulin-resistant states have not been elucidated fully. Recently, we showed that beta-cell adaptation failed dramatically in adult, insulin-resistant POKO mice, which contrasts with the appropriate expansion of beta cells in their ob/ob littermates. Thus, we hypothesised that characterisation of the islets in these...
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