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Article

Identification of islet-enriched long non-coding RNAs contributing to β-cell failure in type 2 diabetes

18 Aug 2017

Abstract excerpt

OBJECTIVE: Non-coding RNAs constitute a major fraction of the β-cell transcriptome. While the involvement of microRNAs is well established, the contribution of long non-coding RNAs (lncRNAs) in the regulation of β-cell functions and in diabetes development remains poorly understood. The aim of this study was to identify novel islet lncRNAs differently expressed in type 2 diabetes models and to investigate their...

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PMID: 29107288
DOI: 10.1016/j.molmet.2017.08.005

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