Article

Intrahepatic reporter assay reveals leaky somatic blockade of L1 retrotransposition in mice

2026-02-12

Abstract excerpt

Long interspersed element-1 (LINE-1, L1) retrotransposition has long been proposed to occur in somatic tissues, yet direct experimental evidence distinguishing adult somatic events from early embryonic insertions has remained limited. Here we establish an intrahepatic L1 reporter assay that enables immunohistochemical detection and quantitative analysis of L1 retrotransposition in vivo . Using autonomous and non-...

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Literature Corpus work: 5119b6ab-be23-5c30-8292-67ede22cca4c
DOI: 10.64898/2026.02.12.705536

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Intrahepatic reporter assay reveals leaky somatic blockade of L1 retrotransposition in miceDOI 10.64898/2026.02.12.705536Read

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