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Article

Identification of rtl1, a retrotransposon-derived imprinted gene, as a novel driver of hepatocarcinogenesis.

PLoS genetics - 1 Apr 2013

Riordan Jesse D, Keng Vincent W, Tschida Barbara R, Scheetz Todd E, Bell Jason B, Podetz-Pedersen Kelly M, Moser Catherine D, Copeland Neal G, Jenkins Nancy A, Roberts Lewis R, Largaespada David A, Dupuy Adam J

Abstract excerpt

We previously utilized a Sleeping Beauty (SB) transposon mutagenesis screen to discover novel drivers of HCC. This approach identified recurrent mutations within the Dlk1-Dio3 imprinted domain, indicating that alteration of one or more elements within the domain provides a selective advantage to cells during the process of hepatocarcinogenesis. For the current study, we performed transcriptome and small RNA...

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Share to Cell Transformation, Neoplastic
Share to Chromosomes, Human, Pair 14

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Genomic Imprinting

Share to Liver Neoplasms

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Source

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Identifiers

PMID: 23593033
DOI: 10.1371/journal.pgen.1003441
PMCID: PMC3616914

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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