Article

An autochthonous model of lung cancer in the Naked Mole-Rat ( <i>Heterocephalus glaber</i> )

2023-08-28

Abstract excerpt

Studies on cancer resistance in the naked mole-rat (NMR) have generally failed to interrogate possible resistance mechanisms in a physiological context. Here, we provide evidence that the NMR presents as a novel model of tumor initiation. We developed an endogenous lung cancer model in NMRs, driven by an oncogenic Eml4-Alk fusion protein introduced through CRISPR- mediated genome editing. While this is sufficient...

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Literature Corpus work: 3d663258-0701-5eb7-b2cb-3661f9e9b74e
DOI: 10.1101/2023.08.28.555115

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