Article
Retroviral elements and their hosts: insertional mutagenesis in the mouse germ line.
PLoS genetics - 1 Jan 2006
Maksakova Irina A, Romanish Mark T, Gagnier Liane, Dunn Catherine A, van de Lagemaat Louie N, Mager Dixie L
Abstract excerpt
The inbred mouse is an invaluable model for human biology and disease. Nevertheless, when considering genetic mechanisms of variation and disease, it is important to appreciate the significant differences in the spectra of spontaneous mutations that distinguish these species. While insertions of transposable elements are responsible for only approximately 0.1% of de novo mutations in humans, the figure is...
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