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Age- and Hypertension-Associated Protein Aggregates in Mouse Heart Have Similar Proteomic Profiles

15 Mar 2016

Abstract excerpt

Neurodegenerative diseases are largely defined by protein aggregates in affected tissues. Aggregates contain some shared components as well as proteins thought to be specific for each disease. Aggregation has not previously been reported in the normal, aging heart or the hypertensive heart. Detergent-insoluble protein aggregates were isolated from mouse heart and characterized on 2-dimensional gels. Their levels...

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PMID: 26975704
DOI: 10.1161/hypertensionaha.115.06849

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