Article
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Cell systems - 22 Apr 2020
Pourhaghighi Reza, Ash Peter E A, Phanse Sadhna, Goebels Florian, Hu Lucas Z M, Chen Siwei, Zhang Yingying, Wierbowski Shayne D, Boudeau Samantha, Moutaoufik Mohamed T, Malty Ramy H, Malolepsza Edyta, Tsafou Kalliopi, Nathan Aparna, Cromar Graham, Guo Hongbo, Abdullatif Ali Al, Apicco Daniel J, Becker Lindsay A, Gitler Aaron D, Pulst Stefan M, Youssef Ahmed, Hekman Ryan, Havugimana Pierre C, White Carl A, Blum Benjamin C, Ratti Antonia, Bryant Camron D, Parkinson John, Lage Kasper, Babu Mohan, Yu Haiyuan, Bader Gary D, Wolozin Benjamin, Emili Andrew
Abstract excerpt
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one...
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