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Aging limits stemness and tumorigenesis in the lung by reprogramming iron homeostasis

2024-06-28

Abstract excerpt

<h4>Summary</h4> Aging is associated with a decline in the number and fitness of adult stem cells 1–4 . Aging-associated loss of stemness is posited to suppress tumorigenesis 5,6 , but this hypothesis has not been tested in vivo . Here, using physiologically aged autochthonous genetically engineered mouse models and primary cells 7,8 , we demonstrate aging suppresses lung cancer initiation and progression by...

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Literature Corpus work
50fa50bb-228b-57d2-97ad-f2b40d420e22
DOI
10.1101/2024.06.23.600305
Open publication

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Aging limits stemness and tumorigenesis in the lung by reprogramming iron homeostasisDOI 10.1101/2024.06.23.600305
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