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A Multi-omic Analysis of the Human Lung Reveals Distinct Cell Specific Aging and Senescence Molecular Programs

2023-04-19

Abstract excerpt

Age is a major risk factor for lung disease. To understand the mechanisms underlying this association, we characterized the changing cellular, genomic, transcriptional, and epigenetic landscape of lung aging using bulk and single-cell RNAseq (scRNAseq) data. Our analysis revealed age-associated gene networks that reflected hallmarks of aging, including mitochondrial dysfunction, inflammation, and cellular senescen...

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Literature Corpus work
00b67ae2-f358-5f2a-b991-9885a3d4b4b1
DOI
10.1101/2023.04.19.536722
Open publication

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A Multi-omic Analysis of the Human Lung Reveals Distinct Cell Specific Aging and Senescence Molecular ProgramsDOI 10.1101/2023.04.19.536722
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