Article

Aging directs the differential evolution of KRAS-driven lung adenocarcinoma

2025-01-24

Abstract excerpt

Lung adenocarcinoma (LUAD), the most common histological subtype of lung cancer( 1, 2 ), is a disease of the elderly, with an average age of diagnosis of about 70 years of age( 3 ). Older age is associated with an increased incidence of KRAS-driven LUAD( 4 ), a particularly deadly type of LUAD characterized by treatment resistance and relapse. Despite this, our understanding of how old age shapes KRAS-driven LU...

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Literature Corpus work: 978efbfc-87d6-5ecc-a564-6c5fe1fd2669
DOI: 10.1101/2025.01.20.633951

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