Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clusterin drives myeloid bias in aged hematopoietic stem cells by regulating mitochondrial function

30 Jun 2025

Abstract excerpt

Aged hematopoietic stem cells (HSCs) exhibit diminished self-renewal and myeloid-biased differentiation with a decline in hematopoiesis and adaptive immune function. However, the molecular regulation of this impaired function remains largely unknown. Here, through an in vivo CRISPR-Cas9-based screen, we uncovered clusterin (Clu) as a driver of biased differentiation. Clu is upregulated in aged HSCs, and its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clusterin in disease pathology
Share to Ferroptosis and cancer prognosis
Share to Mitochondrial Function and Pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40588652
DOI: 10.1038/s43587-025-00908-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clusterin drives myeloid bias in aged hematopoietic stem cells by regulating mitochondrial functionPMID 40588652Read ↗

Tracking clusterin expression in hematopoietic stem cells reveals their heterogeneous composition across the life spanSemantic proximity Read ↗

Aging limits stemness and tumorigenesis in the lung by reprogramming iron homeostasisSemantic proximity Read ↗

Mitochondrial Contributions to Hematopoietic Stem Cell AgingSemantic proximity Read ↗

UTX maintains the functional integrity of the murine hematopoietic system by globally regulating aging-associated genes.Semantic proximity Read ↗

Induction of mitophagy reverts age-associated decline of the hematopoietic and immune systemsSemantic proximity Read ↗

CRISPR-engineered human GATA2 deficiency model uncovers mitotic dysfunction and premature aging in HSPCs, impairing hematopoietic fitness.Semantic proximity Read ↗

Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional declineSemantic proximity Read ↗

Mechanisms and rejuvenation strategies for aged hematopoietic stem cellsSemantic proximity Read ↗

BNIP3L/NIX and FUNDC1-mediated mitophagy is required for mitochondrial network remodeling during cardiac progenitor cell differentiationSemantic proximity Read ↗

Mitophagy in hematopoietic stem cellsSemantic proximity Read ↗

Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62Semantic proximity Read ↗

Restoration of CPEB4 prevents muscle stem cell senescence during agingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.