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Article

Quantifying elongation rhythm during full-length protein synthesis.

Journal of the American Chemical Society - 31 Jul 2013

Rosenblum Gabriel, Chen Chunlai, Kaur Jaskiran, Cui Xiaonan, Zhang Haibo, Asahara Haruichi, Chong Shaorong, Smilansky Zeev, Goldman Yale E, Cooperman Barry S

Abstract excerpt

Pauses regulate the rhythm of ribosomal protein synthesis. Mutations disrupting even minor pauses can give rise to improperly formed proteins and human disease. Such minor pauses are difficult to characterize by ensemble methods, but can be readily examined by single-molecule (sm) approaches. Here we use smFRET to carry out real-time monitoring of the expression of a full-length protein, the green fluorescent...

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Source

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Identifiers

PMID: 23822614
DOI: 10.1021/ja405205c
PMCID: PMC3768011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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