Article

The role of DNA methylation in chondrogenesis of human iPSCs as a stable marker of cartilage quality

2023-09-06

Abstract excerpt

<title>Abstract</title> <p>Background Lack of insight into factors that determine purity and quality of human iPSC (hiPSC)-derived neo-cartilage precludes applications of this powerful technology towards regenerative solutions in the clinical setting. Here we set out to generate methylome-wide landscapes of hiPSC derived neo-cartilages from different tissues-of-origin and integrated transcriptome-wide data to id...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 50f4a66e-df76-55e9-bf0a-ecee938f9e52
DOI: 10.21203/rs.3.rs-3272276/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The role of DNA methylation in chondrogenesis of human iPSCs as a stable marker of cartilage qualityDOI 10.21203/rs.3.rs-3272276/v1Read

The role of DNA methylation in chondrogenesis of human iPSCs as a stable marker of cartilage qualitySemantic proximity Read

DNA hypomethylation during MSC chondrogenesis occurs predominantly at enhancer regionsSemantic proximity Read

Genome-wide map of quantified epigenetic changes during in vitro chondrogenic differentiation of primary human mesenchymal stem cellsSemantic proximity Read

Spatial transcriptomics defines the mechanisms of hiPSC-derived stem cell-mediated repair in human articular cartilageSemantic proximity Read

Single cell transcriptomic analysis of human pluripotent stem cell chondrogenesisSemantic proximity Read

Epigenetic and phenotypic profile of fibroblasts derived from induced pluripotent stem cells.Semantic proximity Read

Prospective Isolation of Chondroprogenitors from Human iPSCs Based on Cell Surface Markers Identified using a CRISPR-Cas9-Generated ReporterSemantic proximity Read

DNA Methylation Profiling in Chondrocyte Dedifferentiation In Vitro.Semantic proximity Read

Epigenomic differences between osteoarthritis grades in primary cartilageSemantic proximity Read

Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives.Semantic proximity Read

Decoding the Regulatory Landscape of Ageing in Musculoskeletal Engineered Tissues Using Genome-Wide DNA Methylation and RNASeqSemantic proximity Read

Leveraging single cell multiomic analyses to identify factors that drive human chondrocyte cell fateSemantic proximity Read