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The role of DNA methylation in chondrogenesis of human iPSCs as a stable marker of cartilage quality

15 Oct 2024

Abstract excerpt

BACKGROUND: Lack of insight into factors that determine purity and quality of human iPSC (hiPSC)-derived neo-cartilage precludes applications of this powerful technology toward regenerative solutions in the clinical setting. Here, we set out to generate methylome-wide landscapes of hiPSC-derived neo-cartilages from different tissues-of-origin and integrated transcriptome-wide data to identify dissimilarities in...

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PMID: 39407288
DOI: 10.1186/s13148-024-01759-y

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