Article

A genome-wide CRISPR activation map of surface protein expression in human CD4 T cells

2026-08-11

Abstract excerpt

Surface proteins define T cell identity and function, but the abundance of each protein is not determined by transcription alone. Existing genome-wide CRISPR screens in primary human T cells either profile the transcriptome or isolate cells based on a single functional or protein phenotype. Here we present SCITO-Perturb-seq, a novel platform that couples combinatorial-indexed single-cell cytometry sequencing with...

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Literature Corpus work: 50ec0ac6-2438-515f-b115-69048bac944e
DOI: 10.64898/2026.08.08.743670

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