Article
Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation.
Cancer research - 15 Nov 2017
Yang Rui, Chen Lee H, Hansen Landon J, Carpenter Austin B, Moure Casey J, Liu Heng, Pirozzi Christopher J, Diplas Bill H, Waitkus Matthew S, Greer Paula K, Zhu Huishan, McLendon Roger E, Bigner Darell D, He Yiping, Yan Hai
Abstract excerpt
Inactivating mutations in the transcriptional repression factor Capicua (CIC) occur in approximately 50% of human oligodendrogliomas, but mechanistic links to pathogenesis are unclear. To address this question, we generated Cic-deficient mice and human oligodendroglioma cell models. Genetic deficiency in mice resulted in a partially penetrant embryonic or perinatal lethal phenotype, with the production of an...
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