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Article

Integrative multi-omic analysis reveals neurodevelopmental gene dysregulation in CIC-knockout and IDH1-mutant cells.

The Journal of pathology - 1 Mar 2022

Lee Stephen D, Song Jungeun, LeBlanc Veronique G, Marra Marco A

Abstract excerpt

Capicua (CIC)'s transcriptional repressor function is implicated in neurodevelopment and in oligodendroglioma (ODG) aetiology. However, CIC's role in these contexts remains obscure, primarily from our currently limited knowledge regarding its biological functions. Moreover, CIC mutations in ODG invariably co-occur with a neomorphic IDH1/2 mutation, yet the functional relationship between these two genetic events...

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Identifiers

PMID: 34767259
DOI: 10.1002/path.5835
PMCID: PMC9305137

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