Article

Senescent peripheral fibroblasts initiate chemotherapy-induced peripheral neuropathy

2026-08-05

Abstract excerpt

<h4>ABSTRACT</h4> Chemotherapy-induced peripheral neuropathy (CIPN) is a common, debilitating complication of cancer therapy. Although axonal degeneration defines CIPN, the initiating cellular events remain unknown. Here, we show that CIPN is initiated by senescent peripheral fibroblasts rather than by the neuron itself. Across the mechanistically distinct chemotherapeutic agents paclitaxel and cisplatin, chemoth...

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Literature Corpus work: 50be695e-bf3a-5868-88de-e7000b69d81a
DOI: 10.64898/2026.08.04.742055

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