Article

Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration after peripheral nerve injury

2022-12-08

Abstract excerpt

After peripheral nerve injuries, successful axonal growth and functional recovery requires the reprogramming of Schwann cells into a reparative phenotype, a process dependent on the activation of the transcription factor c-Jun. Nevertheless, axonal regeneration is greatly impaired in aged organisms or after chronic denervation leading to important clinical problems. This regenerative failure has been associated to...

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Literature Corpus work: 18167d2d-0385-546e-9809-c36150363b08
DOI: 10.1101/2022.12.07.519441

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