Article

Activation of Sarm1 produces cADPR to increase intra-axonal calcium and promote axon degeneration in CIPN

2021-04-15

Abstract excerpt

<h4>SUMMARY</h4> Cancer patients frequently develop chemotherapy-induced peripheral neuropathy (CIPN), a painful and long-lasting disorder with profound somatosensory deficits. There are no effective therapies to prevent or treat this disorder. Pathologically, CIPN is characterized by a “dying-back” axonopathy that begins at intra-epidermal nerve terminals of sensory neurons and progresses in a retrograde fashion...

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Literature Corpus work: ba18133b-4be4-5794-ac6f-17e17e241011
DOI: 10.1101/2021.04.15.440024

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